Endogenous Sleeping Peptide of Sleep
Barbituric acid was synthesized more than 100 years ago. It is found that barbituric acid and its derivatives have hypnotic effects. At the beginning of the twentieth Century, the use of hypnotic and the discussion of its mechanism of action led to a hypothesis that physical activities stimulate the blood vessels to produce "hypnotic", and it is the "hypnotic" that causes sleep. Under the guidance of this view, French psychologist Pieron first discovered in 1910 that when the cerebrospinal fluid of a sleep-deprived dog was extracted and injected into the ventricle of the normal dog, the recipient dogs dozed and fell asleep. They believe that animals have sleep-inducing hypnotic accumulated in cerebrospinal fluid during sleep deprivation. During 1965-1980 years, Pa Pentti Hamel and other experts extracted a chemical called "sleep factor" from the cerebrospinal fluid of the goats that were deprived of sleep, then they injected the "sleep factor"...